Retrospective study regarding the appearance of osteonecrosis related to bisphosphonate therapy.
Identifieur interne : 000057 ( Main/Exploration ); précédent : 000056; suivant : 000058Retrospective study regarding the appearance of osteonecrosis related to bisphosphonate therapy.
Auteurs : Adela Cristina Laz R [Roumanie] ; Roxana Socaciu ; Ovidiu Mure An ; Mariana P CurarSource :
- Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [ 2066-8279 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Diphosphonates.
- étiologie : Ostéonécrose de la mâchoire associée aux biphosphonates.
- Femelle, Humains, Mâle, Études rétrospectives.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Diphosphonates.
- etiology : Bisphosphonate-Associated Osteonecrosis of the Jaw.
- Female, Humans, Male, Retrospective Studies.
Abstract
Bisphosphonates are analogues of the natural compound pyrophosphate and one consequence of the mechanism of action of bisphosphonates on bone metabolism is the reduction of bone turnover, replenish the resorption spaces and to mineralize the extracellular matrix. Osteonecrosis of the jaw is the most common side effect of bisphosphonates and most often occurs after an invasive dental procedure, such as dental extraction. The existence of a maxillary bone infection leads to a delayed healing reaction manifested by the presence of areas necrotic bone, exposed in the oral cavity, which persists for more than eight weeks and has no tendency to heal. In most cases, the dentist is the first one who can detect the onset of osteonecrosis even in the early stages, thus being able to direct the patient to a hospital unit where he/she receives the treatment of necessity. The aim of this retrospective study is to determine the link between bisphosphonate therapy and the occurrence of necrosis of maxillary and mandibular bone. This study was conducted on 22 patients hospitalized for different stages of bone necrosis for a period of two years. The prevalence of osteonecrosis is higher in menopausal women and also after a certain period after the bisphosphonate therapy is closed.
PubMed: 32239099
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Osteonecrosis of the jaw is the most common side effect of bisphosphonates and most often occurs after an invasive dental procedure, such as dental extraction. The existence of a maxillary bone infection leads to a delayed healing reaction manifested by the presence of areas necrotic bone, exposed in the oral cavity, which persists for more than eight weeks and has no tendency to heal. In most cases, the dentist is the first one who can detect the onset of osteonecrosis even in the early stages, thus being able to direct the patient to a hospital unit where he/she receives the treatment of necessity. The aim of this retrospective study is to determine the link between bisphosphonate therapy and the occurrence of necrosis of maxillary and mandibular bone. This study was conducted on 22 patients hospitalized for different stages of bone necrosis for a period of two years. The prevalence of osteonecrosis is higher in menopausal women and also after a certain period after the bisphosphonate therapy is closed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32239099</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>31</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2066-8279</ISSN><JournalIssue CitedMedium="Internet"><Volume>60</Volume><Issue>4</Issue><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie</Title><ISOAbbreviation>Rom J Morphol Embryol</ISOAbbreviation></Journal><ArticleTitle>Retrospective study regarding the appearance of osteonecrosis related to bisphosphonate therapy.</ArticleTitle><Pagination><MedlinePgn>1227-1231</MedlinePgn></Pagination><Abstract><AbstractText>Bisphosphonates are analogues of the natural compound pyrophosphate and one consequence of the mechanism of action of bisphosphonates on bone metabolism is the reduction of bone turnover, replenish the resorption spaces and to mineralize the extracellular matrix. Osteonecrosis of the jaw is the most common side effect of bisphosphonates and most often occurs after an invasive dental procedure, such as dental extraction. The existence of a maxillary bone infection leads to a delayed healing reaction manifested by the presence of areas necrotic bone, exposed in the oral cavity, which persists for more than eight weeks and has no tendency to heal. In most cases, the dentist is the first one who can detect the onset of osteonecrosis even in the early stages, thus being able to direct the patient to a hospital unit where he/she receives the treatment of necessity. The aim of this retrospective study is to determine the link between bisphosphonate therapy and the occurrence of necrosis of maxillary and mandibular bone. This study was conducted on 22 patients hospitalized for different stages of bone necrosis for a period of two years. The prevalence of osteonecrosis is higher in menopausal women and also after a certain period after the bisphosphonate therapy is closed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lazăr</LastName><ForeName>Adela Cristina</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Department of Oral Rehabilitation, Oral Health and Dental Office Management, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; lazar_adela@yahoo.ro.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Socaciu</LastName><ForeName>Roxana</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Mureşan</LastName><ForeName>Ovidiu</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Păcurar</LastName><ForeName>Mariana</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Romania</Country><MedlineTA>Rom J Morphol Embryol</MedlineTA><NlmUniqueID>9112454</NlmUniqueID><ISSNLinking>1220-0522</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004164">Diphosphonates</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D059266" MajorTopicYN="N">Bisphosphonate-Associated Osteonecrosis of the Jaw</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004164" MajorTopicYN="N">Diphosphonates</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32239099</ArticleId><ArticleId IdType="pii">60041912271231</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Roumanie</li></country></list><tree><noCountry><name sortKey="Mure An, Ovidiu" sort="Mure An, Ovidiu" uniqKey="Mure An O" first="Ovidiu" last="Mure An">Ovidiu Mure An</name><name sortKey="P Curar, Mariana" sort="P Curar, Mariana" uniqKey="P Curar M" first="Mariana" last="P Curar">Mariana P Curar</name><name sortKey="Socaciu, Roxana" sort="Socaciu, Roxana" uniqKey="Socaciu R" first="Roxana" last="Socaciu">Roxana Socaciu</name></noCountry><country name="Roumanie"><noRegion><name sortKey="Laz R, Adela Cristina" sort="Laz R, Adela Cristina" uniqKey="Laz R A" first="Adela Cristina" last="Laz R">Adela Cristina Laz R</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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